Description
Childhood fevers, raw throat swelling from tonsillitis, sharp ear aches, and chest congestion brought on by resistant bacterial pathogens require an intelligent, dual-mechanism antibiotic. Fleming 228.5mg/5mL Suspension (70mL) is a widely trusted, precisely dosed pediatric formulation of Co-Amoxiclav tailored for younger children and infants. When standard amoxicillin encounters complex infections, certain mutant bacteria produce defensive enzymes called beta-lactamases that break down the medicine before it can work. Fleming overcomes this molecular defense by pairing a powerful aminopenicillin with a specialized protective shield, making it an incredibly effective first-line solution for modern childhood infections.
The high-performance clinical success of Fleming 228.5mg relies on its advanced dual-action cell wall destruction pathway:
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The Beta-Lactamase Deactivation Shield: The Clavulanic Acid (28.5mg) molecule acts as a decoy inhibitor. It binds permanently to the destructive beta-lactamase enzymes secreted by the bacteria, completely neutralizing them before they can touch the antibiotic core.
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The Unhindered Core Attack: With the bacterial defenses down, the high-purity Amoxicillin (200mg) molecule easily passes through the cell membrane to lock onto essential Penicillin-Binding Proteins (PBPs).
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Rapid Osmotic Lysis: The amoxicillin completely blocks the cell wall’s structural cross-linking. Lacking a rigid exterior shell to handle internal osmotic pressures, the bacteria quickly swell up, burst open, and dissolve, allowing your child’s immune system to stabilize.
Key Benefits of Fleming 228.5mg/5mL Pediatric Suspension
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Overcomes Antibiotic Resistance: The smart addition of Potassium Clavulanate protects the antibiotic molecule, making it highly effective against difficult, resistant respiratory and ear strains.
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Tailored for Infants and Toddlers: The 228.5mg per 5mL strength configuration allows for precise, micro-calculated dosing based exactly on the weight of younger pediatric patients.
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Excellent Pediatric Tissue Penetration: Reaches deep, highly effective therapeutic concentrations in fluid-heavy spaces like the middle ear cavity, nasal sinuses, lung tissue, and urinary tracts.
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Sealed Dry Powder Configuration: Safely packaged as a dry, free-flowing powder in an amber glass bottle to fully shield the active ingredients from heat and humidity until you are ready to mix it.
Specifications
| Feature | Details |
| Product Title | Fleming 228.5mg/5mL Powder for Oral Suspension (70mL) |
| Active Ingredients | Amoxicillin (200mg) + Clavulanic Acid (28.5mg) per 5mL |
| Therapeutic Class | Co-Amoxiclav (Beta-Lactam Antibiotic + Beta-Lactamase Inhibitor) |
| Formulation Type | Dry powder for reconstitution into oral suspension |
| Pack Size Volume | 70mL total volume capacity once reconstituted |
| Manufacturer / Distributor | Medreich Limited / Sanofi-Aventis Nigeria Limited |
| Regulatory Status | Prescription-Only Medicine (POM) / NAFDAC Registered |
Reconstitution & Strict Administration Instructions: For oral use only. Fleming 228.5mg is a highly potent prescription antibiotic. It must be taken exactly as directed by your pediatrician or medical professional. Never stop the treatment early—even if your child’s fever completely breaks, their energy returns, or their earache clears within 48 hours. Stopping early leaves the strongest bacteria alive, which can cause a highly dangerous, resistant relapse. How to Reconstitute: 1. Tap the glass bottle gently a few times to loosen the dry powder inside. 2. Carefully add boiled, cooled water up to the graduation mark etched on the glass bottle or product label. 3. Close the cap tightly, invert the bottle completely, and shake vigorously for 30 to 60 seconds until all powder turns into a smooth, off-white suspension. Allow it to sit for 5 minutes to ensure full dissolution. How to Administer: Always shake the bottle well before drawing each dose. Use an accurate oral dosing syringe or medicinal spoon to measure the exact milliliter line prescribed. Administer right at the start of a meal or snack to minimize potential stomach upset and maximize absorption. Storage Care (Crucial): Store the unopened dry powder below 25°C in a dry place. Once mixed with water, the liquid suspension MUST be stored inside a refrigerator (2°C to 8°C). Do not freeze. Discard any remaining, unused medication completely after 7 days of liquid storage.
⚠️ Clinical Disclaimer & Patient Safety Warning
Critical Medical Warning: Fleming suspension is strictly formulated to eliminate bacterial pathogens. It has no effect against viral particles and will never treat, cure, or manage a viral cold, seasonal flu, viral coughs, or standard viral catarrh. The Penicillin Allergy Alert: Do not administer this medication if the child has a known history of severe hypersensitivity or immediate allergic shock reactions to Amoxicillin, Clavulanic acid, standard Penicillins, or Cephalosporin class drugs. Allergic reactions can be serious and require immediate emergency medical care. Phenylketonuria (PKU) Warning: This formulation contains aspartame (a source of phenylalanine) inside its flavoring base. It must be avoided or used with extreme caution in children diagnosed with Phenylketonuria. Mononucleosis Rash Interaction: Do not use Fleming if the child is suspected of having infectious mononucleosis (glandular fever). The amoxicillin component can interact with this viral profile to trigger a severe, widespread, non-allergic skin rash.
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